New research finds method to accelerate bone healing process

According to the Centers for Disease Control and Prevention, fractures are the most common nonfatal injuries for adults in the U.S. over 65 years old. They also account for 61 percent of nonfatal care costs. Once these fractures occur, the healing process is generally very slow.

A study by Duke Medicine has found a new strategy to accelerate the process. The researchers manipulated the bone healing process in older mice by transplanting bone marrow and circulating blood from a younger mouse into an older mouse. The scientists found that this caused the bones to heal more efficiently and quickly in the aging mouse. 

In past studies, Duke scientists discovered the major role of a protein called beta-catenin in the bone healing process. In order for the protein to work effectively in bone repair, it requires specific modulation. During the early stages of bone repair in older adults, the levels of beta-catenin become elevated, which causes the production of tissue that is similar to scar instead of bone, inhibiting the healing process.

The beta-catenin levels were manipulated in the study by exposing the older mice to blood circulation of younger animals, ultimately correcting the formula for healthy bone repair. These findings suggest that drug therapies may be able to lower beta-catenin levels to improve fracture repair in older adults and even younger patients with bone implants.